Université Lyon 1
Université de Lyon
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Accueil  >>  Master  >>  Chimie  >>  Synthesis, catalysis and sustainable chemistry  >>  Self evolving molecular systems
  • Domaine : Masters du domaine SCIENCES, TECHNOLOGIES, SANTE
  • Diplôme : Master
  • Mention : Chimie
  • Parcours : Synthesis, catalysis and sustainable chemistry
  • Unité d'enseignement : Self evolving molecular systems
Nombre de crédits de l'UE : 3
Code APOGEE : CHM2251M
UE Obligatoire pour ce parcours
UE valable pour le semestre 3 de ce parcours
    Responsabilité de l'UE :
STRAZEWSKI PIOTR
 piotr.strazewskiuniv-lyon1.fr
04.72.44.82.34
    Type d'enseignement
Nb heures *
Cours Magistraux (CM)
18 h
Travaux Dirigés (TD)
0 h
Travaux Pratiques (TP)
0 h
Total du volume horaire
18 h

* Ces horaires sont donnés à titre indicatif.

    Conditions d'accès à l'UE :
First year graduate level courses in organic chemistry and undergraduate level courses in biochemistry
    Programme - Contenu de l'UE :

 Course objectives: to provide an overview of the current state-of-the-art in Systems Chemistry, and where this

relatively young chemical field is heading for. Systems Chemistry aims at demonstrating and reconstructing the

accumulation of complex matter, in order to find the chemical roots of biological organization. The main issue of the

course is to study on a timeline the spontaneous growth in size, abundance and organization of organic molecular

systems.

The spontaneous formation of the building blocks of life

Amino acids from the elements H, C, O, N and S; long chain alcohols and carboxylic acids from dihydrogen and

carbon monoxide, aromatic N-heterocycles from simple precursors like hydrogen cyanide, formamide, guanidine

or cyanamide; carbohydrates from formaldehyde: the formose reaction; nucleosides from N-heterocycles and

carbohydrates; alternatives to the classical prebiotic reaction pathways

Spontaneous condensation reactions of the building blocks of life

Peptides from amino acids; oligosaccharides from simple sugars; nucleic acids from nucleosides and phosphate

; lipids and fats from glycerol, amino alcohols, phosphate and long chain carboxylic (fatty) acids; mixed conjugates

from lipids and sugars, peptides and nucleic acids, lipids and nucleic acids, etc.

Molecular and supramolecuar properties of organic macromolecules

Liposomes from lipids; globular aggregations and extended architectures from peptides; folded nucleic acids; the

interaction of organic macromolecules with small organic molecules; the interaction of liposomes with organic

macromolecules

Systemic approach to the chemical origin of life

Boundaries for compartmented chemical systems from organic amphiphiles; self-templating nucleic acids and

peptides; autocatalytic and crosscatalytic chemical reaction networks; the origin of homochirality; compartmented

templating reactions and catalytic reaction networks; growth and division of natural compartments

What is life? How Chemistry becomes Biology

How to keep a dynamic chemical system out of thermodynamic equilibrium; the concept of dynamic kinetic

stability; how to maintain the concentration of useful catalysts in a replicating chemical system over many generations;

the concept of evolvability and self-evolvability; self-evolving synthetic living cells from the entirely inanimate

Evolvable molecular systems for sustainable development

Non biotic evolvable systems; perspectives for evolvable catalysts and materials

    Compétences acquises :
Méthodologiques :

 Acquired Skills: an understanding of the fundamental requirements underlying evolvable molecular systems; a knowledge

of the biomolecules and of their interactions, and of the hierarchy of compositional and dynamic chemical complexity;

a conceptual distinction between chemical building blocks, composition, complexity of composition on the one

hand, and chemical transformation, dynamics and complexity of chemical interactions on the other.



Techniques :
n/a
    Modalités de contrôle des connaissances et Compétences 2020-2021:
TypeLibelléNatureCoef. 
CTContrôle TerminalCT : Self evolv. mol. systemsEcrit session 1 / Ecrit session 23
    Liste des autres Parcours / Spécialité / Filière / Option utilisant cette UE :
Date de la dernière mise-à-jour : 31/08/2017
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