The goal of this UE is to provide an overview and recent advances on cell death and cellular aging fields. During this teaching program the emphasis will be put on how both fields are critical to understand the aging process.
Lectures on different topics of cell death and cellular aging will be given in English, by expert professors and researchers of the French scientific community; the scientists will present overviews and recent advances of those rapidly growing fields. The conferences will be followed by round table discussions with the experts.
Then, choosing one of the lectures as starting point, students will go deeper into it and propose a research project including: a short “state of the art”, biological questions to be answered, experimental strategies to be performed and expected results.
The following topics will be addressed:
- Biology of cell death: necrosis, necroptosis, apoptosis and autophagy and their relationship to aging
- Cellular senescence: molecular mechanisms of control and escaping
- Cellular aging and damage to the molecules: reactive oxygen species, protein aggregation, telomere shortening
- Cellular aging and metabolism: theories of caloric restriction, metabolic signalling pathways
- Physiopathology of aging: organisms’ longevity, aging diseases and neurodegenerative diseases
