Université Lyon 1
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  • Unité d'enseignement : Assemblies for diagnostics, imaging and therapy
Nombre de crédits de l'UE : 3
Code APOGEE : CHM2349M
    Responsabilité de l'UE :
TRIMAILLE THOMAS
 thomas.trimailleuniv-lyon1.fr
04.72.44.81.97
    Type d'enseignement
Nb heures *
Cours Magistraux (CM)
18 h

* Ces horaires sont donnés à titre indicatif.

    Pré-requis :

Knowledge in polymer chemistry

    Compétences attestées (transversales, spécifiques) :

-          To know the challenges/issues and requirements of diagnostics, imaging and therapy

-          To know the (macro)molecular assemblies used in these topics, their preparation methods, their physicochemical properties

-          To be able to link the requirements of the application to the structure and elaboration mode of (macro)molecular assemblies

    Programme de l'UE / Thématiques abordées :

1-Introduction

1.1-Reminders on bioactive molecules (drugs, nucleic acids, proteins) in interaction with polymer systems

            1.2-Medical diagnostics: definition, challenges, ELISA method

            1.3-Medical imaging: presentation of the major imaging techniques

            1.4-Therapy: role of drug delivery systems, pharmacokinetics, pharmacodynamics, targeting methods

            1.5-Interaction modes between polymer systems and-bioactive molecules

 

2- Colloids

            2.1-Colloids obtained from preformed polymers

                        - Polyesters: their synthesis, their formulation into colloidal systems, drug encapsulation and release

                        - Polyelectrolyte complexes as protein carriers

            2.2- Application of colloids to in vitro medical diagnostics

            2.3- Lipid-based colloids

                        Elaboration, caracterization, surface modification, drug encapsulation, diagnostic, therapeutic and dermatologic applications

 

3- Water-soluble polymers and hydrogels

            3.1-Elaboration of water-soluble polymer / biomolecule conjugates (polyelectrolytes, neutral polymers, amphiphilic polymers) for in vitro diagnostics, medical imaging and drug delivery.

            3.2-Hydrogels: elaboration, applications to drug delivery and as artificial organs.

Date de la dernière mise-à-jour : 16/12/2022
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