* Ces horaires sont donnés à titre indicatif.
- Basic knowledge of the anatomo-functional organization of the nervous system at the molecular and cellular levels
- Basic knowledge of the cell biology (gene expression, protein synthesis, intracellular communication, electric signal genesis…)
- Basic knowledge of the principal steps of the development of the nervous system, synaptic communication, brain plasticity.
- Basic knowledge of the experimental tools enabling to study the neuronal morphology and activity as single neuronal unit and neuronal networks
- Know how to search bibliographic databases, identify pertinent publications related to a topic and synthetize information (written and oral synthesis)
- Know how to combine and integrate different levels of analysis to identify and characterize the neural bases of a behavior in both physiological and pathological contexts.
- Know how to critically analyze experimental results originating from these different levels of analysis
- Know how to use classical and the most recent neurobiology and neurophysiology tools to investigate the cellular mechanisms underlying neuronal activity, neuronal development, synaptic communication and plasticity, in different animal models: know their respective advantages and limits.
- Being able to describe and critically analyze molecular mechanisms responsible for neuronal activity (voltage- gated channels, chemo-dependency…) synaptic communication and plasticity, neuronal integration, neuronal metabolism, neuronal differentiation, synaptogenesis, maintenance of the homeostasis of the nervous system thanks to neuron-glia interaction.
- Know how to implement an empirical process based on electrophysiology recordings and use of computational modeling of neuronal activity (protocol elaboration, data curation and analysis)
Understanding the biochemical and electrical specificities of the neuronal cells is the first step toward understanding brain function and information processing. In this teaching unit, lectures will provide detailed description of the neuronal activity (genesis, firing patterns, propagation…), of the synaptic communication and its plasticity, of neuronal integration, neuronal metabolism, neuronal differentiation and synaptogenesis, maintenance of the homeostasis of the nervous system thanks to neuron-glia interaction. In group works, analysis of scientific articles will allow students to master the concepts underlying the most recent technics in neurobiology and electrophysiology unitary recordings and develop critical reading. In practical courses, students will perform unitary recordings in invertebrate neurons and will develop a scientific protocol to identify the main modulators of neuronal activity. This empirical approach will be complemented by the use of a computational model of neuronal activity.