* Ces horaires sont donnés à titre indicatif.
Knowledge in polymer chemistry
- To know the challenges/issues and requirements of diagnostics, imaging and therapy
- To know the (macro)molecular assemblies used in these topics, their preparation methods, their physicochemical properties
- To be able to link the requirements of the application to the structure and elaboration mode of (macro)molecular assemblies
1-Introduction
1.1-Reminders on bioactive molecules (drugs, nucleic acids, proteins) in interaction with polymer systems
1.2-Medical diagnostics: definition, challenges, ELISA method
1.3-Medical imaging: presentation of the major imaging techniques
1.4-Therapy: role of drug delivery systems, pharmacokinetics, pharmacodynamics, targeting methods
1.5-Interaction modes between polymer systems and-bioactive molecules
2- Colloids
2.1-Colloids obtained from preformed polymers
- Polyesters: their synthesis, their formulation into colloidal systems, drug encapsulation and release
- Polyelectrolyte complexes as protein carriers
2.2- Application of colloids to in vitro medical diagnostics
2.3- Lipid-based colloids
Elaboration, caracterization, surface modification, drug encapsulation, diagnostic, therapeutic and dermatologic applications
3- Water-soluble polymers and hydrogels
3.1-Elaboration of water-soluble polymer / biomolecule conjugates (polyelectrolytes, neutral polymers, amphiphilic polymers) for in vitro diagnostics, medical imaging and drug delivery.
3.2-Hydrogels: elaboration, applications to drug delivery and as artificial organs.